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Recombinant Human TGF-beta 1 Protein

(240-B-010)



概述
货号 240-B-010
简介 A New TGF-beta 1 is Available! The new protein is Hek293 expressed!
New Product 7754-BH
别名 CEDLAP; DPD1; latency-associated peptide; TGFB; TGFB1; TGF-beta 1 protein; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1
全称 Transforming Growth Factor beta 1
反应种属 Human
形式 Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
性能
供应商 R&D Systems
Entrez Gene IDs 7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine); 100033900 (Equine)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition
Authors: Qisheng Li
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
Authors: Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P
Eur J Immunol, 2016;46(1):212-22.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells
Cancer Res, 2016;0(0):.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
MAP3K19 Is a Novel Regulator of TGF-? Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis
PLoS ONE, 2016;11(5):e0154874.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Cell-cell contact and matrix adhesion promote ?SMA expression during TGF?1-induced epithelial-myofibroblast transition via Notch and MRTF-A
Sci Rep, 2016;6(0):26226.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue
Authors: Mohadeseh Mehrabian
PLoS ONE, 2016;11(6):e0156779.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Nat Commun, 2016;7(0):12092.

Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes
Stem Cell Reports, 2016;0(0):.
Species: Human
Sample Type: protein
Application: ELISA Standard
Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation
Nat Commun, 2016;7(0):12603.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Transforming Growth Factor-? Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors
Clin Cancer Res, 2016;0(0):.
Species: Human
Sample Type: Whole Cell
Application: Bioassay
CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits
Authors: Martine Schrøder
PLoS ONE, 2016;11(6):e0157387.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure
Authors: Shoko Ohno
Sci Rep, 2016;6(0):27192.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Dietary n-3 PUFA Protects Mice from Con A Induced Liver Injury by Modulating Regulatory T Cells and PPAR-gamma Expression.
Authors: Lian M, Luo W, Sui Y, Li Z, Hua J
PLoS ONE, 2015;10(7):e0132741.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
JNK-dependent gene regulatory circuitry governs mesenchymal fate.
Authors: Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M, Tiwari V
EMBO J, 2015;34(16):2162-81.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy.
Authors: Pessina P, Cabrera D, Morales M, Riquelme C, Gutierrez J, Serrano A, Brandan E, Munoz-Canoves P
Skelet Muscle, 2015;4(0):7.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.
Authors: Kaushansky N, Eisenstein M, Boura-Halfon S, Hansen B, Nielsen C, Milo R, Zeilig G, Lassmann H, Altmann D, Ben-Nun A
J Biol Chem, 2015;290(24):15260-78.
Species: Mouse
Sample Type: Cell Culture SupernatesT cell
Application: ELISA Standard
BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses.
Authors: Young K, Tweedie E, Conley B, Ames J, FitzSimons M, Brooks P, Liaw L, Vary C
PLoS ONE, 2015;10(4):e0122892.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining.
Authors: Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y
Proc Natl Acad Sci U S A, 2015;113(5):1256-60.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
Invest Ophthalmol Vis Sci, 2015;56(2):1051-62.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells.
Authors: Sun, Yue, Deng, Wei, Geng, Linyu, Zhang, Lu, Liu, Rui, Chen, Weiwei, Yao, Genhong, Zhang, Huayong, Feng, Xuebing, Gao, Xiang, Sun, Lingyun
J Immunol Res, 2015;2015(0):284215.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Drak2 Does Not Regulate TGF-beta Signaling in T Cells.
Authors: Harris T, McGargill M
PLoS ONE, 2015;10(5):e0123650.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
5Z-7-Oxozeanol Inhibits the Effects of TGFbeta1 on Human Gingival Fibroblasts.
Authors: Kuk H, Hutchenreuther J, Murphy-Marshman H, Carter D, Leask A
PLoS ONE, 2015;10(4):e0123689.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
CXCL13 antibody for the treatment of autoimmune disorders.
Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
BMC Immunol, 2015;16(0):6.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Effects of sodium citrate and acid citrate dextrose solutions on cell counts and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel.
Authors: Giraldo C, Alvarez M, Carmona J
BMC Vet Res, 2015;11(0):60.
Species: Equine
Sample Type: Plasma Lysate

Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells.
Authors: Fujita T, Chiwaki F, Takahashi R, Aoyagi K, Yanagihara K, Nishimura T, Tamaoki M, Komatsu M, Komatsuzaki R, Matsusaki K, Ichikawa H, Sakamoto H, Yamada Y, Fukagawa T, Katai H, Konno H, Ochiya T, Yoshida T, Sasaki H
PLoS ONE, 2015;10(6):e0130808.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway.
Authors: Yu D, Zhang C, Zhao S, Zhang S, Zhang H, Cai S, Shao R, He H
Acta Pharmacol Sin, 2015;36(4):473-82.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination.
Authors: Masani S, Han L, Meek K, Yu K
Proc Natl Acad Sci U S A, 2015;113(5):1261-6.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche.
Authors: Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu-Kaoud N, Halabi N, Guerrouahen B, Rafii S, Rafii A
J Transl Med, 2015;13(0):27.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
TGF-beta1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.
Authors: Pang M, Georgoudaki A, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander J, Nelson C, Jakobsson L, Betsholtz C, Sund M, Karlsson M, Fuxe J
Oncogene, 2015;35(6):748-60.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression.
Authors: Kinugasa H, Whelan K, Tanaka K, Natsuizaka M, Long A, Guo A, Chang S, Kagawa S, Srinivasan S, Guha M, Yamamoto K, St Clair D, Avadhani N, Diehl J, Nakagawa H
Oncogene, 2015;34(41):5229-39.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Lipoxin A4 Attenuates Constitutive and TGF-beta1-Dependent Profibrotic Activity in Human Lung Myofibroblasts.
Authors: Roach K, Feghali-Bostwick C, Amrani Y, Bradding P
J Immunol, 2015;195(6):2852-60.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
Authors: Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W
Nat Immunol, 2015;16(10):1077-84.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis.
Authors: Mehrabian M, Brethour D, Wang H, Xi Z, Rogaeva E, Schmitt-Ulms G
PLoS ONE, 2015;10(8):e0133741.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans.
Authors: Waight J, Takai S, Marelli B, Qin G, Hance K, Zhang D, Tighe R, Lan Y, Lo K, Sabzevari H, Hofmeister R, Wilson N
J Immunol, 2015;194(3):878-82.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes.
Authors: Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S
Stem Cells, 2015;33(3):742-50.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development.
Authors: Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y
Cancer Res, 2015;75(2):306-15.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs.
Authors: Presnell S, Al-Attar A, Cichocki F, Miller J, Lutz C
Genes Immun, 2015;16(1):89-98.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Salinomycin and other polyether ionophores are a new class of antiscarring agent.
Authors: Woeller C, O'Loughlin C, Roztocil E, Feldon S, Phipps R
J Biol Chem, 2015;290(6):3563-75.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.
Authors: Nguyen L, Pan J, Dinh T, Hadeiba H, O'Hara E, Ebtikar A, Hertweck A, Gokmen M, Lord G, Jenner R, Butcher E, Habtezion A
Nat Immunol, 2015;16(2):207-13.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
Nature, 2015;518(7539):417-21.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice.
Authors: Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J
PLoS ONE, 2015;10(3):e0121939.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells.
Authors: Woltje K, Jabs M, Fischer A
PLoS ONE, 2015;10(3):e0120547.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells.
Authors: Cruet-Hennequart S, Drougard C, Shaw G, Legendre F, Demoor M, Barry F, Lefaix J, Galera P
PLoS ONE, 2015;10(3):e0119334.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-beta pathway.
Authors: Schmitt-Ney M, Camussi G
PLoS ONE, 2015;10(3):e0121474.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
4-1BB ligand signaling to T cells limits T cell activation.
Authors: Eun S, Lee S, Xu Y, Croft M
J Immunol, 2015;194(1):134-41.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.
Authors: Wei D, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry J, Stepan G, Stray K, Tsai A, Yu H, Spindler J, Kearney M, Spina C, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T
PLoS Pathog, 2014;10(4):e1004071.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The anti-proliferative function of the TGF-beta1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3.
Authors: Li J, Ballim D, Rodriguez M, Cui R, Goding C, Teng H, Prince S
J Biol Chem, 2014;289(51):35633-43.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling.
Authors: Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson C, Mukhopadhyay N, Fisher P, Sarkar D
FEBS Open Bio, 2014;4(0):353-61.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Inhibitory effects of PPARgamma ligands on TGF-beta1-induced corneal myofibroblast transformation.
Authors: Jeon K, Kulkarni A, Woeller C, Phipps R, Sime P, Hindman H, Huxlin K
Am J Pathol, 2014;184(5):1429-45.
Species: Feline
Sample Type: Whole Cells
Application: Bioassay
Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases.
Authors: Ueda J, Matsuda Y, Yamahatsu K, Uchida E, Naito Z, Korc M, Ishiwata T
Oncogene, 2014;33(36):4485-95.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Expression of insulin-like growth factor 2 receptor in corneal keratocytes during differentiation and in response to wound healing.
Authors: Bohnsack R, Warejcka D, Wang L, Gillespie S, Bernstein A, Twining S, Dahms N
Invest Ophthalmol Vis Sci, 2014;55(12):7697-708.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
Authors: Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A
Int J Oncol, 2014;45(1):393-400.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Effective chemoimmunotherapy with anti-TGFbeta antibody and cyclophosphamide in a mouse model of breast cancer.
Authors: Chen X, Yang Y, Zhou Q, Weiss J, Howard O, McPherson J, Wakefield L, Oppenheim J
PLoS ONE, 2014;9(1):e85398.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
JAK/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells.
Authors: Liu R, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang H
Int J Oncol, 2014;44(5):1643-51.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells.
Authors: Solomon J, Heitzer M, Liu T, Beumer J, Parise R, Normolle D, Leach D, Buchanan G, DeFranco D
Mol Cancer Res, 2014;12(8):1166-80.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Transforming growth factor-beta-induced miR143 expression in regulation of non-small cell lung cancer cell viability and invasion capacity in vitro and in vivo.
Authors: Cheng T, Hu C, Yang H, Cao L, An J
Int J Oncol, 2014;45(5):1977-88.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney.
Authors: Zhou Y, Xiong M, Niu J, Sun Q, Su W, Zen K, Dai C, Yang J
J Cell Sci, 2014;127(0):4494-506.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.
Authors: Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D
J Immunol, 2014;193(3):1047-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis.
Authors: Gobel K, Schuhmann M, Pankratz S, Stegner D, Herrmann A, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth S
Eur J Immunol, 2014;44(8):2295-305.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation.
Authors: Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G
J Biol Chem, 2014;289(51):35246-63.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma.
Authors: Okabe H, Delgado E, Lee J, Yang J, Kinoshita H, Hayashi H, Tsung A, Behari J, Beppu T, Baba H, Monga S
PLoS ONE, 2014;9(6):e98817.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Protein tyrosine phosphatase alpha mediates profibrotic signaling in lung fibroblasts through TGF-beta responsiveness.
Authors: Aschner Y, Khalifah A, Briones N, Yamashita C, Dolgonos L, Young S, Campbell M, Riches D, Redente E, Janssen W, Henson P, Sap J, Vacaresse N, Kapus A, McCulloch C, Zemans R, Downey G
Am J Pathol, 2014;184(5):1489-502.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression.
Authors: Chen C, Akiyama K, Yamaza T, You Y, Xu X, Li B, Zhao Y, Shi S
EMBO Mol Med, 2014;6(3):322-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density.
Authors: Kim D, Lee M, Yoo K, Lee T, Kim H, Jang I, Chun Y, Kim H, Park S, Lee S, Son M, Jung H, Sung K, Koo H
PLoS ONE, 2014;9(1):e83363.
Species: Human
Sample Type: Whole Cells
Application: cell culture
Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis.
Authors: Zheng J, Wu C, Lin Z, Guo Y, Shi L, Dong P, Lu Z, Gao S, Liao Y, Chen B, Yu F
FEBS J, 2014;281(1):88-103.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Authors: Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H
Nat Med, 2014;20(1):62-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A signal transduction pathway from TGF-beta1 to SKP2 via Akt1 and c-Myc and its correlation with progression in human melanoma.
Authors: Qu X, Shen L, Zheng Y, Cui Y, Feng Z, Liu F, Liu J
J Invest Dermatol, 2014;134(1):159-67.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice.
Authors: Haffner-Luntzer, Melanie, Heilmann, Aline, Rapp, Anna Eli, Beie, Simon, Schinke, Thorsten, Amling, Michael, Ignatius, Anita, Liedert, Astrid
PLoS ONE, 2014;9(12):e116282.
Species: Mouse
Sample Type: whole cells
Application: Bioassay
Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-beta signaling pathway.
Authors: Wang X, Gui L, Zhang Y, Zhang J, Shi J, Xu G
Int J Oncol, 2014;44(4):1099-106.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Inhibition of periostin expression protects against the development of renal inflammation and fibrosis.
Authors: Mael-Ainin M, Abed A, Conway S, Dussaule J, Chatziantoniou C
J Am Soc Nephrol, 2014;25(8):1724-36.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
The AMPK agonist AICAR inhibits TGF-beta1 induced activation of kidney myofibroblasts.
Authors: Chen K, Hsu H, Lee C, Yen T, Ko Y, Yang C, Hung C
PLoS ONE, 2014;9(9):e106554.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin.
Authors: Kumawat K, Menzen M, Slegtenhorst R, Halayko A, Schmidt M, Gosens R
PLoS ONE, 2014;9(4):e94801.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Binding of AID to DNA does not correlate with mutator activity.
Authors: Matthews A, Husain S, Chaudhuri J
J Immunol, 2014;193(1):252-7.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Chromatinized protein kinase C-theta directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells.
Authors: Zafar A, Wu F, Hardy K, Li J, Tu W, McCuaig R, Harris J, Khanna K, Attema J, Gregory P, Goodall G, Harrington K, Dahlstrom J, Boulding T, Madden R, Tan A, Milburn P, Rao S
Mol Cell Biol, 2014;34(16):2961-80.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis.
Authors: Pan C, Kumar S, Shah N, Hoyt D, Hawinkels L, Mythreye K, Lee N
J Biol Chem, 2014;289(37):25486-96.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-beta signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.
Authors: Schwartze J, Becker S, Sakkas E, Wujak L, Niess G, Usemann J, Reichenberger F, Herold S, Vadasz I, Mayer K, Seeger W, Morty R
J Biol Chem, 2014;289(6):3262-75.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation.
Authors: Miller C, Haas U, Diaz R, Leeper N, Kundu R, Patlolla B, Assimes T, Kaiser F, Perisic L, Hedin U, Maegdefessel L, Schunkert H, Erdmann J, Quertermous T, Sczakiel G
PLoS Genet, 2014;10(3):e1004263.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Transforming growth factor beta signaling overcomes dasatinib resistance in lung cancer.
Authors: Gordian E, Li J, Pevzner Y, Mediavilla-Varela M, Luddy K, Ohaegbulam K, Daniel K, Haura E, Munoz-Antonia T
PLoS ONE, 2014;9(12):e114131.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Musashi-2 controls cell fate, lineage bias, and TGF-beta signaling in HSCs.
Authors: Park S, Deering R, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert B, Hacohen N, Leslie C, Daley G, Lengner C, Kharas M
J Exp Med, 2014;211(1):71-87.
Species: Human
Sample Type: whole cells
Application: Bioassay
Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation.
Authors: Yu Y, Yiang G, Chou P, Tseng H, Wu T, Hung Y, Lin P, Lin S, Liu H, Chang W, Wei C
Mol Med Rep, 2014;9(6):2077-84.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
The fate of the primary cilium during myofibroblast transition.
Authors: Rozycki M, Lodyga M, Lam J, Miranda M, Fatyol K, Speight P, Kapus A
Mol Biol Cell, 2014;25(5):643-57.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Follicular dendritic cell secreted protein FDC-SP controls IgA production.
Authors: Hou S, Landego I, Jayachandran N, Miller A, Gibson I, Ambrose C, Marshall A
Mucosal Immunol, 2014;7(4):948-57.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
Authors: Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, van Erp C, Gerber E, Parker S, Sauls K, Judge D, Cooke S, Lindsay M, Rouf R, Myers L, ap Rhys C, Kent K, Norris R, Huso D, Dietz H
J Clin Invest, 2014;124(1):448-60.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Induction of immunoregulatory CD271+ cells by metastatic tumor cells that express human endogenous retrovirus H.
Authors: Kudo-Saito C, Yura M, Yamamoto R, Kawakami Y
Cancer Res, 2014;74(5):1361-70.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement.
Authors: Truchetet M, Brembilla N, Montanari E, Lonati P, Raschi E, Zeni S, Fontao L, Meroni P, Chizzolini C
Arthritis Rheum, 2013;65(5):1347-56.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
Authors: Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M
Eur J Immunol, 2013;43(7):1727-34.
Species: Mouse
Sample Type: whole cells
Application: cell culture
Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.
Authors: Ammann J, Cooke A, Trowsdale J
J Immunol, 2013;190(10):5030-6.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
TGF-beta1 promotes lymphangiogenesis during peritoneal fibrosis.
Authors: Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y
J Am Soc Nephrol, 2013;24(10):1627-42.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation.
Authors: Yasmin N, Bauer T, Modak M, Wagner K, Schuster C, Koffel R, Seyerl M, Stockl J, Elbe-Burger A, Graf D, Strobl H
J Exp Med, 2013;210(12):2597-610.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Neuropilin-2 Is upregulated in lung cancer cells during TGF-beta1-induced epithelial-mesenchymal transition.
Authors: Nasarre P, Gemmill R, Potiron V, Roche J, Lu X, Baron A, Korch C, Garrett-Mayer E, Lagana A, Howe P, Drabkin H
Cancer Res, 2013;73(23):7111-21.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
Authors: Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing
Nat Genet, 2013;45(1):34-42.
Species: Mouse
Sample Type: whole cells
Application: Bioassay
Canonical transforming growth factor-beta signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
Authors: Ramdas V, McBride M, Denby L, Baker A
Am J Pathol, 2013;183(6):1885-96.
Species: Rat
Sample Type: whole cells
Application: Bioassay
MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney.
Authors: Long, Jianyin, Badal, Shawn S, Wang, Yin, Chang, Benny H, Rodriguez, Antony, Danesh, Farhad R
J Biol Chem, 2013;288(51):36202-14.
Species: Mouse
Sample Type: whole cells
Application: cell culture
MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms.
Authors: Liu Y, Yin J, Abou-Kheir W, Hynes P, Casey O, Fang L, Yi M, Stephens R, Seng V, Sheppard-Tillman H, Martin P, Kelly K
Oncogene, 2013;32(3):296-306.
Species: Mouse
Sample Type: whole cells
Application: Cell Culture Substrate
Role of IGF-1 pathway in lung fibroblast activation.
Authors: Hung C, Rohani M, Lee S, Chen P, Schnapp L
Respir Res, 2013;14(0):102.
Species: Mouse
Sample Type: Whole Cells
Application: cell culture
Transforming growth factor β-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis.
Am J Pathol, 2013;182(1):118-31.
Species: Mouse
Sample Type: whole cells
Application: Bioassay
Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression.
Authors: Keune W, Sims A, Jones D, Bultsma Y, Lynch J, Jirstrom K, Landberg G, Divecha N
Cancer Res, 2013;73(23):6913-25.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
FOG2 protein down-regulation by transforming growth factor-beta1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy.
Authors: Park J, Kato M, Yuan H, Castro N, Lanting L, Wang M, Natarajan R
J Biol Chem, 2013;288(31):22469-80.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin.
Authors: Tannetta D, Dragovic R, Gardiner C, Redman C, Sargent I
PLoS ONE, 2013;8(2):e56754.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture.
Authors: Nguyen H, Zhuang Y, Sun L, Kantrow S, Kolls J, You Z, Zhuo Y, Shan B
Cancer Cell Int, 2013;13(1):16.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis.
Authors: Leung L, Radulovich N, Zhu C, Wang D, To C, Ibrahimov E, Tsao M
PLoS ONE, 2013;8(12):e84366.
Species: Human
Sample Type: cells
Application: cell culture
TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses.
Authors: Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H
J Immunol, 2013;191(11):5420-9.
Species: Mouse
Sample Type: whole cells
Application: cell culture
TGF-beta mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells.
Authors: Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini F, Andreeff M, Kuratsu J, Lang F
Cancer Res, 2013;73(7):2333-44.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-beta1 and platelet-derived growth factor BB.
Authors: Xu Z, Zhang Q, Li H
Mol Med Rep, 2013;8(6):1715-21.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells.
Authors: Wang C, Yi T, Qin L, Maldonado R, von Andrian U, Kulkarni S, Tellides G, Pober J
J Clin Invest, 2013;123(4):1677-93.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis.
Authors: Geng L, Chaudhuri A, Talmon G, Wisecarver J, Wang J
PLoS ONE, 2013;8(3):e59918.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition.
Authors: Balli D, Ustiyan V, Zhang Y, Wang I, Masino A, Ren X, Whitsett J, Kalinichenko V, Kalin T
EMBO J, 2013;32(2):231-44.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
Nature, 2012;487(7408):505-9.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
TGF beta1-Induced Baf60c Regulates both Smooth Muscle Cell Commitment and Quiescence.
Authors: Sohni A, Mulas F, Ferrazzi F, Luttun A, Bellazzi R, Huylebroeck D, Ekker S, Verfaillie C
PLoS ONE, 2012;7(10):e47629.
Species: Rat
Sample Type: Whole Cells
Application: Bioassay
Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma.
Authors: Abushahba W, Olabisi O, Jeong B, Boregowda R, Wen Y, Liu F, Goydos J, Lasfar A, Cohen-Solal K
PLoS ONE, 2012;7(10):e47312.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma.
Authors: Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J
PLoS ONE, 2012;7(10):e46117.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
T-Lymphocytes Enable Osteoblast Maturation via IL-17F during the Early Phase of Fracture Repair.
Authors: Nam D, Mau E, Wang Y, Wright D, Silkstone D, Whetstone H, Whyne C, Alman B
PLoS ONE, 2012;7(6):e40044.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
Authors: Flanagan K, Fitzgerald K, Baker J
PLoS ONE, 2012;7(7):e40443.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis.
Authors: Kudo, Yasusei, Iizuka, Shinji, Yoshida, Maki, Tsunematsu, Takaaki, Kondo, Tomoyuki, Subarnbhesaj, Ajiravud, Deraz, Elsayed, Siriwardena, Samadara, Tahara, Hidetosh, Ishimaru, Naozumi, Ogawa, Ikuko, Takata, Takashi
J Biol Chem, 2012;287(46):38716-28.
Species: Human
Sample Type: whole cells
Application: Bioassay
Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.
Authors: Bruce D, Macartney T, Yong W, Shou W, Sapkota G
Cell Signal, 2012;24(11):1999-2006.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Targeting Axl with an high-affinity inhibitory aptamer.
Authors: Cerchia, Laura, Esposito, Carla L, Camorani, Simona, Rienzo, Anna, Stasio, Loredana, Insabato, Luigi, Affuso, Andrea, de Franciscis, Vittorio
Mol Ther, 2012;20(12):2291-303.
Species: Human
Sample Type: whole cells
Application: Bioassay
Hic-5 promotes invadopodia formation and invasion during TGF-beta-induced epithelial-mesenchymal transition.
Authors: Pignatelli J, Tumbarello DA, Schmidt RP, Turner CE
J. Cell Biol., 2012;197(3):421-37.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Authors: Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D
J. Immunol., 2012;188(10):4866-75.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis.
Authors: Krishnan A, Li X, Kao W, Viker K, Butters K, Masuoka H, Knudsen B, Gores G, Charlton M
Lab Invest, 2012;92(12):1712-25.
Species: Human
Sample Type: whole cells
Application: Bioassay
Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis.
J. Exp. Med., 2012;209(11):2033-47.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells.
Nat. Med., 2012;1248(0):18.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A Local Paracrine and Endocrine Network Involving TGF beta, Cox-2, ROS, and Estrogen Receptor beta Influences Reactive Stromal Cell Regulation of Prostate Cancer Cell Motility.
Authors: Grubisha MJ, Cifuentes ME, Hammes SR, Defranco DB
Mol. Endocrinol., 2012;26(6):940-54.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.
Authors: Mottershead D, Ritter L, Gilchrist R
Mol Hum Reprod, 2012;18(3):121-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors.
Clin. Cancer Res., 2012;18(15):4122-35.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma.
Authors: Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S
PLoS Pathog., 2012;8(1):e1002486.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients.
Authors: Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y
J Biol Chem, 2012;287(42):35484-95.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
PLoS Biol, 2012;10(9):e1001395.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma.
Authors: Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M
Am. J. Pathol., 2012;180(1):365-74.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Authors: Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH
J. Immunol., 2012;188(4):2001-13.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion.
Authors: Henriksson ML, Edin S, Dahlin AM, Oldenborg PA, Oberg Ã…, Van Guelpen B, Rutegard J, Stenling R, Palmqvist R
Am. J. Pathol., 2011;178(3):1387-94.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers.
Authors: Sierra-Filardi E, Puig-Kroger A, Blanco FJ, Nieto C, Bragado R, Palomero MI, Bernabeu C, Vega MA, Corbi AL
Blood, 2011;117(19):5092-101.

Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction.
Authors: Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K
Am. J. Pathol., 2011;178(2):572-9.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
J. Exp. Med., 2011;208(3):491-503.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha.
Authors: Gibbings S, Elkins ND, Fitzgerald H, Tiao J, Weyman ME, Shibao G, Fini MA, Wright RM
J. Biol. Chem., 2011;286(2):961-75.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice.
Authors: Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirstrom K, Magnusson K, Ebert BL, Ponten F, Weinberg RA, McAllister SS
J. Clin. Invest., 2011;121(2):784-99.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.
Authors: Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, Delaporte M, Xu K, Aubertin AM, Moog C
J. Virol., 2011;85(2):1077-85.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.
Authors: Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H
Cell, 2011;147(5):1146-58.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung.
Authors: Hoffman AM, Paxson JA, Mazan MR, Davis AM, Tyagi S, Murthy S, Ingenito EP
Stem Cells Dev., 2011;20(10):1779-92.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Glycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation.
Authors: Duchez S, Pascal V, Cogne N, Jayat-Vignoles C, Julien R, Cogne M
Eur. J. Immunol., 2011;41(12):3632-44.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
Authors: Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
Mol. Biol. Cell, 2011;22(10):1686-98.
Species: Canine
Sample Type: Whole Cells
Application: Bioassay
Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
FASEB J., 2011;25(1):409-19.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer.
Authors: Zheng L, Foley K, Huang L, Leubner A, Mo G, Olino K, Edil BH, Mizuma M, Sharma R, Le DT, Anders RA, Illei PB, Van Eyk JE, Maitra A, Laheru D, Jaffee EM
PLoS ONE, 2011;6(4):e19390.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Authors: Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY
Diabetologia, 2011;54(10):2713-23.
Species: N/A
Sample Type: N/A
Application: ELISA Standard
Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis.
Authors: Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T
Proc. Natl. Acad. Sci. U.S.A., 2011;108(34):14222-7.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Transcription factor Dlx2 protects from TGFbeta-induced cell-cycle arrest and apoptosis.
Authors: Yilmaz M, Maass D, Tiwari N, Waldmeier L, Schmidt P, Lehembre F, Christofori G
EMBO J., 2011;30(21):4489-99.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Development and characterisation of an assay for furin activity.
Authors: Bourne GL, Grainger DJ
J. Immunol. Methods, 2011;364(1):101-8.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
内毒素水平

<0.10 EU per 1 μg of the protein by the LAL method.
生物活性 Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is typically 0.04-0.2 ng/mL.
The specific activity of Recombinant Human TGF-beta 1 is approximately 2.5 x 104 U/μg, which is calibrated against human TGF‑ beta 1 Standard (NIBSC code: 89/514).
溶解方法 Purified recombinant human TGF-beta 1 is an extremely hydrophobic protein that adheres strongly to surfaces. To ensure recovery, reconstitute at 20 μg/mL in sterile 4 mM HCl containing 1 mg/mL human or bovine serum albumin.
背景

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure (1‑7). TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1‑4). Each TGF-beta isoform has some non‑redundant functions; for TGF-beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature human TGF‑ beta 1 shares 100% aa identity with pig, dog and cow TGF‑ beta 1, and 99% aa identity with mouse, rat and horse TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta  RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

Accession # P01137
N-terminal
Sequence Analysis
Ala279
预期分子量 12.8 (monomer) kDa
SDS-PAGE 12 kDa, reducing conditions
24 kDa, non-reducing conditions
纯度 >97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
不含载体 What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

参考文献
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  8. Derynck, R. et al. (1985) Nature 316:701.
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  10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
  11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
  12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.
参考图片
1 ug/lane of Recombinant Human TGF-beta 1 was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by silver staining, showing single bands at 12 kDa and 24 kDa, respectively.
Recombinant Human TGF-beta 1 (Catalog # 240-B) inhibits Recombinant Mouse IL‑4 (Catalog # 404-ML) induced proliferation in the HT-2 mouse T cell line. The ED50 for this effect is typically 0.04-0.2 ng/mL.
Epithelial to Mesenchymal Transition (EMT) was induced in the A549 human lung carcinoma cell line with cell culture media supplemented with Recombinant Human (rh)TGF-beta 1 (Catalog # 240-B). Control cells were cultured without rhTGF-beta 1. EMT induction was confirmed at 48 h by flow cytometric staining for E-Cadherin (filled; Catalog # FAB18381P), an epithelial cell marker, or an isotype control(Catalog # 240-B). TGF-beta 1 decreased the expression of E-Cadherin.
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