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Recombinant Mouse GM-CSF Protein

(415-ML-050)



概述
货号 415-ML-050
别名 colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; CSF2; GM-CSF; GMCSFgranulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony stimulating factor; MGC131935; MGC138897; molgramostin; sargramostim
全称 Granulocyte Macrophage Growth Factor
反应种属 Mouse
形式 Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
性能
供应商 R&D Systems
Entrez Gene IDs 1437 (Human); 12981 (Mouse); 116630 (Rat); 397208 (Porcine); 403923 (Canine); 493805 (Feline)
应用文献
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells
Authors: Jonatan Ersching
PLoS Pathog, 2016;12(6):e1005698.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A Fusion Protein Consisting of the Vaccine Adjuvant Monophosphoryl Lipid A and the Allergen Ovalbumin Boosts Allergen-Specific Th1, Th2, and Th17 Responses In Vitro
Authors: Stefan Schülke
J Immunol Res, 2016;2016(0):4156456.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassays
A Lipid Based Antigen Delivery System Efficiently Facilitates MHC Class-I Antigen Presentation in Dendritic Cells to Stimulate CD8(+) T Cells
Authors: Mithun Maji
Sci Rep, 2016;6(0):27206.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies
Authors: Kei Suzuki
PLoS ONE, 2016;11(6):e0156719.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages
Sci Rep, 2016;6(0):29673.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells
J Leukoc Biol, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Alternatively activated macrophages determine repair of the infarcted adult murine heart
J Clin Invest, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus
Authors: Ahmed S Elshikha
PLoS ONE, 2016;11(5):e0156583.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi
PLoS Pathog, 2016;12(4):e1005593.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Hepatitis C Virus Stimulates Murine CD8?-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner
PLoS Pathog, 2016;12(7):e1005736.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Dendritic Cell-Like Cells Accumulate in Regenerating Murine Skeletal Muscle after Injury and Boost Adaptive Immune Responses Only upon a Microbial Challenge
PLoS ONE, 2016;11(5):e0155870.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection
Authors: D Torres, A Köhler, S Delbauve, I Caminschi, MH Lahoud, K Shortman, V Flamand
PLoS Pathog, 2016;12(4):e1005561.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Bone Marrow CD11c+ Cell-Derived Amphiregulin Promotes Pulmonary Fibrosis
J Immunol, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses
PLoS ONE, 2016;11(5):e0155650.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU)
PLoS ONE, 2016;11(5):e0155953.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1.
Authors: Wang H, Bei L, Shah C, Hu L, Eklund E
J Immunol, 2015;194(11):5375-87.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Differential adjuvant activities of TLR7 and TLR9 agonists inversely correlate with nitric oxide and PGE2 production.
Authors: Lee J, Martinez N, West K, Kornfeld H
PLoS ONE, 2015;10(4):e0123165.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells.
Authors: Nakano H, Moran T, Nakano K, Gerrish K, Bortner C, Cook D
J Immunol, 2015;194(8):3808-19.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Authors: Wang Y, Su L, Morin M, Jones B, Whitby L, Surakattula M, Huang H, Shi H, Choi J, Wang K, Moresco E, Berger M, Zhan X, Zhang H, Boger D, Beutler B
Proc Natl Acad Sci U S A, 2015;113(7):E884-93.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Glycogen Synthase Kinase-3beta (GSK-3beta) Inhibition Enhances Dendritic Cell-based Cancer Vaccine Potency via Suppression of Interferon-gamma-induced Indoleamine 2,3-Dioxygenase Expression.
Authors: Noh K, Son K, Jung I, Kang T, Choi C, Park Y
J Biol Chem, 2015;290(19):12394-402.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38.
Authors: Liang X, Liu Y, Mei S, Zhang M, Xin J, Zhang Y, Yang R
PLoS ONE, 2015;10(3):e0121510.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways.
Authors: Anthony S, Howard M, Hailemichael Y, Overwijk W, Schluns K
PLoS ONE, 2015;10(3):e0120274.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The renal microenvironment modifies dendritic cell phenotype.
Authors: Chessa F, Mathow D, Wang S, Hielscher T, Atzberger A, Porubsky S, Gretz N, Burgdorf S, Grone H, Popovic Z
Kidney Int, 2015;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Targeting DNA vaccines to myeloid cells using a small peptide.
Authors: Ye C, Choi J, Abraham S, Shankar P, Manjunath N
Eur J Immunol, 2015;45(1):82-8.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Immunosuppression in early postnatal days induces persistent and allergen-specific immune tolerance to asthma in adult mice.
Authors: Chen, Yan, Zhang, Jin, Lu, Yong, Wang, Libo
PLoS ONE, 2015;10(4):e0122990.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Cytokine-induced killer cells co-cultured with dendritic cells loaded with the protein lysate produced by radiofrequency ablation induce a specific antitumor response.
Authors: Shan, Chan-Cha, Shi, Liang-Ro, Ding, Mei-Qian, Zhu, Yi-Bei, Li, Xiao-Don, Xu, Bin, Jiang, Jing-Tin, Wu, Chang-Pi
Oncol Lett, 2015;9(4):1549-1556.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Authors: Sun C, Schattgen S, Pisitkun P, Jorgensen J, Hilterbrand A, Wang L, West J, Hansen K, Horan K, Jakobsen M, O'Hare P, Adler H, Sun R, Ploegh H, Damania B, Upton J, Fitzgerald K, Paludan S
J Immunol, 2015;194(4):1819-31.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Hematopoietic stem/progenitor cells express several functional sex hormone receptors-novel evidence for a potential developmental link between hematopoiesis and primordial germ cells.
Authors: Mierzejewska K, Borkowska S, Suszynska E, Suszynska M, Poniewierska-Baran A, Maj M, Pedziwiatr D, Adamiak M, Abdel-Latif A, Kakar S, Ratajczak J, Kucia M, Ratajczak M
Stem Cells Dev, 2015;24(8):927-37.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer.
Authors: Gao F, Liu C, Guo J, Sun W, Xian L, Bai D, Liu H, Cheng Y, Li B, Cui J, Zhang C, Cai J
Sci Rep, 2015;5(0):9613.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
An A2B Adenosine Receptor Agonist Promotes Th17 Autoimmune Responses in Experimental Autoimmune Uveitis (EAU) via Dendritic Cell Activation.
Authors: Chen M, Liang D, Zuo A, Shao H, Kaplan H, Sun D
PLoS ONE, 2015;10(7):e0132348.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Authors: Wertz I, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman R, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother W, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee W, Goodnow C, Balazs M, Yu K, Kolumam G, Dixit V
Nature, 2015;528(7582):370-5.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210.
Authors: Noman M, Janji B, Hu S, Wu J, Martelli F, Bronte V, Chouaib S
Cancer Res, 2015;75(18):3771-87.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Immune suppressive effects of tonsil-derived mesenchymal stem cells on mouse bone-marrow-derived dendritic cells.
Authors: Park, Minhwa, Kim, Yu-Hee, Ryu, Jung-Hwa, Woo, So-Youn, Ryu, Kyung-Ha
Stem Cells Int, 2015;2015(0):106540.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis.
Authors: Sahin E, Brunner J, Kral J, Kuttke M, Hanzl L, Datler H, Paar H, Neuwinger N, Saferding V, Zinser E, Halfmann A, Soukup K, Hainzl E, Lohmeyer T, Niederreiter B, Haider T, Dohnal A, Kronke G, Bluml S, Schabbauer G
J Immunol, 2015;195(6):2560-70.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
CD41 marks the initial myelo-erythroid lineage specification in adult mouse hematopoiesis: redefinition of murine common myeloid progenitor.
Authors: Miyawaki K, Arinobu Y, Iwasaki H, Kohno K, Tsuzuki H, Iino T, Shima T, Kikushige Y, Takenaka K, Miyamoto T, Akashi K
Stem Cells, 2015;33(3):976-87.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo.
Authors: Ptaschinski C, Mukherjee S, Moore M, Albert M, Helin K, Kunkel S, Lukacs N
PLoS Pathog, 2015;11(6):e1004978.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Pneumococal Surface Protein A (PspA) Regulates Programmed Death Ligand 1 Expression on Dendritic Cells in a Toll-Like Receptor 2 and Calcium Dependent Manner.
Authors: Vashishta M, Khan N, Mehto S, Sehgal D, Natarajan K
PLoS ONE, 2015;10(7):e0133601.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Protease activity of Per a 10 potentiates Th2 polarization by increasing IL-23 and OX40L.
Authors: Agrawal K, Kale S, Arora N
Eur J Immunol, 2015;45(12):3375-85.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.
Authors: Talaei N, Yu T, Manion K, Bremner R, Wither J
J Immunol, 2015;195(10):4623-31.

Colony-stimulating factor-1 signaling suppresses renal crystal formation.
Authors: Taguchi K, Okada A, Kitamura H, Yasui T, Naiki T, Hamamoto S, Ando R, Mizuno K, Kawai N, Tozawa K, Asano K, Tanaka M, Miyoshi I, Kohri K
J Am Soc Nephrol, 2014;25(8):1680-97.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Maltose-binding protein fusion allows for high level bacterial expression and purification of bioactive mammalian cytokine derivatives.
Authors: Pennati A, Deng J, Galipeau J
PLoS ONE, 2014;9(9):e106724.
Species: N/A
Sample Type: N/A
Application: WB Standard
DHX15 senses double-stranded RNA in myeloid dendritic cells.
Authors: Lu H, Lu N, Weng L, Yuan B, Liu Y, Zhang Z
J Immunol, 2014;193(3):1364-72.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis.
Authors: Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M
Blood, 2014;124(9):1393-403.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis.
Authors: Ko H, Brady J, Ryg-Cornejo V, Hansen D, Vremec D, Shortman K, Zhan Y, Lew A
J Immunol, 2014;192(5):2202-9.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation.
Authors: Noman M, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, Bronte V, Chouaib S
J Exp Med, 2014;211(5):781-90.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Subcapsular sinus macrophages limit dissemination of West Nile virus particles after inoculation but are not essential for the development of West Nile virus-specific T cell responses.
Authors: Winkelmann E, Widman D, Xia J, Johnson A, Van Rooijen N, Mason P, Bourne N, Milligan G
Virology, 2014;450(0):278-89.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Cytokine conditioning enhances systemic delivery and therapy of an oncolytic virus.
Authors: Ilett E, Kottke T, Donnelly O, Thompson J, Willmon C, Diaz R, Zaidi S, Coffey M, Selby P, Harrington K, Pandha H, Melcher A, Vile R
Mol Ther, 2014;22(10):1851-63.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
TRAF5 negatively regulates TLR signaling in B lymphocytes.
Authors: Buchta C, Bishop G
J Immunol, 2014;192(1):145-50.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma.
Authors: Shibata T, Habiel D, Coelho A, Kunkel S, Lukacs N, Hogaboam C
J Immunol, 2014;192(8):3569-81.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
MHC class II transactivator is an in vivo regulator of osteoclast differentiation and bone homeostasis co-opted from adaptive immunity.
Authors: Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari N, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S
J Bone Miner Res, 2014;29(2):290-303.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Functional education of invariant NKT cells by dendritic cell tuning of SHP-1.
Authors: Napolitano, Anna, Pittoni, Paola, Beaudoin, Lucie, Lehuen, Agnes, Voehringer, David, MacDonald, H Robson, Dellabona, Paolo, Casorati, Giulia
J Immunol, 2013;190(7):3299-308.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The leukemia-associated Mll-Ell oncoprotein induces fibroblast growth factor 2 (Fgf2)-dependent cytokine hypersensitivity in myeloid progenitor cells.
Authors: Shah, Chirag A, Bei, Ling, Wang, Hao, Platanias, Leonidas, Eklund, Elizabet
J Biol Chem, 2013;288(45):32490-505.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Emulsified phosphatidylserine, simple and effective peptide carrier for induction of potent epitope-specific T cell responses.
Authors: Ichihashi, Toru, Satoh, Toshifum, Sugimoto, Chihiro, Kajino, Kiichi
PLoS ONE, 2013;8(3):e60068.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.
Authors: Kumar M, Roe K, Orillo B, Muruve D, Nerurkar V, Gale M, Verma S
J Virol, 2013;87(7):3655-67.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Respiratory syncytial virus infection modifies and accelerates pulmonary disease via DC activation and migration.
Authors: Jang, Sihyug, Smit, Joost, Kallal, Lara E, Lukacs, Nicholas
J Leukoc Biol, 2013;94(1):5-15.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer.
Authors: Vermeer D, Spanos W, Vermeer P, Bruns A, Lee K, Lee J
Int J Cancer, 2013;133(1):120-9.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Dectin-1 regulates IL-10 production via a MSK1/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers.
Authors: Elcombe S, Naqvi S, van den Bosch M, Mackenzie K, Cianfanelli F, Brown G, Arthur J
PLoS ONE, 2013;8(3):e60086.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Fas-associated phosphatase 1 (Fap1) influences betacatenin activity in myeloid progenitor cells expressing the Bcr-abl oncogene.
Authors: Huang W, Bei L, Eklund E
J Biol Chem, 2013;288(18):12766-76.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands.
Authors: Munich S, Sobo-Vujanovic A, Buchser W, Beer-Stolz D, Vujanovic N
Oncoimmunology, 2012;1(7):1074-1083.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Macrophages participate in IL-17-mediated inflammation.
Authors: Barin JG, Baldeviano GC, Talor MV, Wu L, Ong S, Quader F, Chen P, Zheng D, Caturegli P, Rose NR, Cihakova D
Eur. J. Immunol., 2012;42(3):726-36.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function.
Authors: Charles, Julia F, Hsu, Lih-Yun, Niemi, Erene C, Weiss, Arthur, Aliprantis, Antonios, Nakamura, Mary C
J Clin Invest, 2012;122(12):4592-605.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Protein kinase C delta (PKCdelta)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia.
Authors: Noh KT, Son KH, Jung ID, Kang HK, Hwang SA, Lee WS, You JC, Park YM
J. Biol. Chem., 2012;287(17):14226-33.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Breast regression protein-39 (BRP-39) promotes dendritic cell maturation in vitro and enhances Th2 inflammation in murine model of asthma.
Authors: Xu Q, Chai S, Qian Y, Zhang M, Wang K
Acta Pharmacol Sin, 2012;33(12):1525-32.
Species: Mouse
Sample Type: whole cells
Application: Cell Culture Substrate
The MSHA Strain of Pseudomonas Aeruginosa Activated TLR Pathway and Enhanced HIV-1 DNA Vaccine Immunoreactivity.
Authors: Hou J, Liu Y, Liu Y, Shao Y
PLoS ONE, 2012;7(10):e47724.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Smad1 signaling restricts hematopoietic potential after promoting hemangioblast commitment.
Authors: Cook BD, Liu S, Evans T
Blood, 2011;117(24):6489-97.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells.
Authors: Kinzfogl J, Hangoc G, Broxmeyer HE
Blood, 2011;118(3):565-75.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Dysregulation in Retinal Para-Inflammation and Age-Related Retinal Degeneration in CCL2 or CCR2 Deficient Mice.
Authors: Chen M, Forrester JV, Xu H
PLoS ONE, 2011;6(8):e22818.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
CCL20/CCR6 blockade enhances immunity to RSV by impairing recruitment of DC.
Authors: Kallal LE, Schaller MA, Lindell DM, Lira SA, Lukacs NW
Eur. J. Immunol., 2010;40(4):1042-52.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Oncostatin M induces dendritic cell maturation and Th1 polarization.
Authors: Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM
Biochem. Biophys. Res. Commun., 2010;394(2):272-8.
Species: Mouse
Sample Type: Whole Cells
Application: Media Supplement - Cell Prep
Critical roles of inflammation and apoptosis in improved survival in a model of hyperoxia-induced acute lung injury in Pneumocystis murina-infected mice.
Authors: Beck JM, Preston AM, Wilcoxen SE, Morris SB, Sturrock A, Paine R
Infect. Immun., 2009;77(3):1053-60.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation.
Authors: Claudio E, Sonder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U
J. Immunol., 2009;182(3):1617-30.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
Authors: Fukui R, Saitoh S, Matsumoto F, Kozuka-Hata H, Oyama M, Tabeta K, Beutler B, Miyake K
J. Exp. Med., 2009;206(6):1339-50.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia.
Authors: Liu Q, Cheng LI, Yi L, Zhu N, Wood A, Changpriroa CM, Ward JM, Jackson SH
Am. J. Pathol., 2009;174(1):153-63.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Adenosine receptors in regulation of dendritic cell differentiation and function.
Authors: Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, Blackburn MR, Biaggioni I, Carbone DP, Feoktistov I, Dikov MM
Blood, 2008;112(5):1822-31.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells.
Authors: Lau AW, Biester S, Cornall RJ, Forrester JV
J. Immunol., 2008;180(6):3889-99.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
Authors: Guo B, Chang EY, Cheng G
J. Clin. Invest., 2008;118(5):1680-90.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
Authors: Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J
Blood, 2007;109(5):2234-42.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells.
Authors: Kurooka M, Kaneda Y
Cancer Res., 2007;67(1):227-36.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation.
Authors: Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic NL, Li LY
J. Immunol., 2007;179(6):3742-51.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma.
Authors: Matsumoto K, Fukuyama S, Eguchi-Tsuda M, Nakano T, Matsumoto T, Matsumura M, Moriwaki A, Kan-o K, Wada Y, Yagita H, Shin T, Pardoll DM, Patcharee R, Azuma M, Nakanishi Y, Inoue H
Biochem. Biophys. Res. Commun., 2007;365(1):170-5.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity.
Authors: Fritz JH, Le Bourhis L, Sellge G, Magalhaes JG, Fsihi H, Kufer TA, Collins C, Viala J, Ferrero RL, Girardin SE, Philpott DJ
Immunity, 2007;26(4):445-59.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
Authors: Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N
Nature, 2007;450(7171):825-31.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells.
Authors: Gaudreau S, Guindi C, Menard M, Besin G, Dupuis G, Amrani A
J. Immunol., 2007;179(6):3638-47.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Lentiviral vector-mediated autonomous differentiation of mouse bone marrow cells into immunologically potent dendritic cell vaccines.
Authors: Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R
Mol. Ther., 2007;15(5):971-80.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Angiostatin inhibits monocyte/macrophage migration via disruption of actin cytoskeleton.
Authors: Perri SR, Annabi B, Galipeau J
FASEB J., 2007;21(14):3928-36.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Differing effects of clarithromycin and azithromycin on cytokine production by murine dendritic cells.
Authors: Sugiyama K, Shirai R, Mukae H, Ishimoto H, Nagata T, Sakamoto N, Ishii H, Nakayama S, Yanagihara K, Mizuta Y, Kohno S
Clin. Exp. Immunol., 2007;147(3):540-6.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Bone marrow-derived cells require a functional glucose 6-phosphate transporter for normal myeloid functions.
Authors: Kim SY, Nguyen AD, Gao JL, Murphy PM, Mansfield BC, Chou JY
J. Biol. Chem., 2006;281(39):28794-801.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.
Authors: Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X
Biochem. Biophys. Res. Commun., 2006;345(3):1122-30.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation.
Authors: Dikov MM, Ohm JE, Ray N, Tchekneva EE, Burlison J, Moghanaki D, Nadaf S, Carbone DP
J. Immunol., 2005;174(1):215-22.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
GM-CSF action in the CNS decreases food intake and body weight.
Authors: Reed JA, Clegg DJ, Smith KB, Tolod-Richer EG, Matter EK, Picard LS, Seeley RJ
J. Clin. Invest., 2005;115(11):3035-44.
Species: Rat
Sample Type: In Vivo
Application: In Vivo
Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines.
Authors: Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M
Anticancer Res., 2005;25(1):299-303.

Robust conversion of marrow cells to skeletal muscle with formation of marrow-derived muscle cell colonies: a multifactorial process.
Authors: Abedi M, Greer DA, Colvin GA, Demers DA, Dooner MS, Harpel JA, Weier HU, Lambert JF, Quesenberry PJ
Exp. Hematol., 2004;32(5):426-34.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs.
Authors: Borg C, Jalil A, Laderach D, Maruyama K, Wakasugi H, Charrier S, Ryffel B, Cambi A, Figdor C, Vainchenker W, Galy A, Caignard A, Zitvogel L
Blood, 2004;104(10):3267-75.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Dendritic cells phagocytose and are activated by Treponema pallidum.
Authors: Bouis DA, Popova TG, Takashima A, Norgard MV
Infect. Immun., 2001;69(1):518-28.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function.
Authors: Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP
Clin. Cancer Res., 1999;5(10):2963-70.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Stem cell factor improves the repopulating ability of primitive hematopoietic stem cells after sublethal irradiation (and, to a lesser extent) after bone marrow transplantation in mice.
Authors: Gardner RV, Oliver P, Astle CM
Stem Cells, 1998;16(2):112-9.
Species: Mouse
Sample Type: In Vivo
Application: In Vivo
Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.
Authors: Liu F, Poursine-Laurent J, Wu HY, Link DC
Blood, 1997;90(7):2583-90.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
TLR2 deletion promotes arthritis through reduction of IL-10.
Authors: Huang Q, Koessler R, Birkett R, Perlman H, Xing L, Pope R
J Leukoc Biol, 0;93(5):751-9.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay

内毒素水平 <1.0 EU per 1 μg of the protein by the LAL method.
生物活性 Measured in a cell proliferation assay using DA3 mouse myeloma cells. Ihle, J.N. et al. (1984) Advances in Viral Oncology. In G. Klein (eds): Raven Press, New York, NY. 4:95. The ED50 for this effect is typically 5‑30 pg/mL.
溶解方法 Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
背景

GM-CSF was initially characterized as a factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM-CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM-CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3-5). It shows clinical effectiveness in ameliorating chemotherapy-induced neutropenia, and GM-CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM-CSF, similar to IL-3 and IL-5, is a cytokine with a core of four bundled alpha ‑helices (8-10). Mature mouse GM-CSF shares 49%-54% amino acid sequence identity with canine, feline, human, and porcine GM-CSF and 69% with rat GM‑CSF. GM‑CSF exerts its biological effects through a heterodimeric receptor complex composed of GM-CSF R alpha /CD116 and the signal transducing common beta chain (CD131) which is also a component of the high-affinity receptors for IL-3 and IL-5 (11, 12). In addition, GM-CSF binds a naturally occurring soluble form of GM-CSF R alpha (13). The activity of GM-CSF is species specific between human and mouse. Mouse GM-CSF is only weakly active on rat cells, although rat GM‑CSF is fully active on mouse cells (14, 15).

Accession # Q14AD9
运输条件 Blue Ice
N-terminal
Sequence Analysis
Met
预期分子量 14.3 kDa
存放说明 M-20C
纯度 >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
不含载体 What does CF mean?
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

参考文献
  1. Martinez-Moczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. 112:653.
  2. Barreda, D.R. et al. (2004) Dev. Comp. Immunol. 28:509.
  3. Eksioglu, E.A. et al. (2007) Exp. Hematol. 35:1163.
  4. Cao, Y. (2007) J. Clin. Invest. 117:2362.
  5. Fleetwood, A.J. et al. (2005) Crit. Rev. Immunol. 25:405.
  6. Heuser, M. et al. (2007) Semin. Hematol. 44:148.
  7. Hege, K.M. et al. (2006) Int. Rev. Immunol. 25:321.
  8. Kaushansky, K. et al. (1992) Biochemistry 31:1881.
  9. Diederichs, K. et al. (1991) Science 254:1779.
  10. Gough, N.M. et al. (1984) Nature 309:763.
  11. Onetto-Pothier, N. et al. (1990) Blood 75:59.
  12. Hayashida, K. et al. (1990) Proc. Natl. Acad. Sci. 87:9655.
  13. Pelley, J.L. et al. (2007) Exp. Hematol. 35:1483.
  14. Oaks, M.K. et al. (1995) J. Interferon Cytokine Res. 15:1095.
  15. Vandenabeele, P. et al. (1990) Lymphokine Res. 9:381.
参考图片
Recombinant Mouse GM-CSF (Catalog # 415-ML) stimulates cell proliferation of the DA3 mouse myeloma cell line. The ED50 for this effect is typically 5-30 pg/mL.
1 μg/lane of Recombinant Mouse GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.
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